Section on Endocrinology
References from
Summer/Fall Newsletter

GROWTH HORMONE SHOULD NOT BE ADMINISTERED ROUTINELY TO CHILDREN WITH SHORT STATURE DUE TO INTRAUTERINE GROWTH RETARDATION WHO ARE NOT CLASSICALLY GROWTH HORMONE DEFICIENT
Allen W. Root, MD
Departments of Pediatrics, Biochemistry and Molecular Biology,
University of South Florida College of Medicine,
Tampa, FL
All Children's Hospital, St. Petersburg, Florida

References

Botero D, Lifshitz F. Intrauterine growth retardation and long-term effects on growth. Curr Opin Pediatr 11:340-347,1999. Chatelain P, Peretti N, Lapillonne A, Nicolino M, Salle B, et al. New insights into the postnatal growth of infants born "idiopathic' small for gestational age. J Pediatr Endocrinol Metab 14:1515-1519,2001.

Coutant R, Carel J-C, Letrait M, Bouvattier C, Chatelain P, Coste J, Chaussain J-L. Short stature associated with intrauterine growth retardation: Final height of untreated and growth hormone-treated children. J Clin Endocrinol Metab 83:1070-1074,1998.

de Zegher F. Growth hormone treatment in intrauterine growth retardation. 84th Annual Meeting of the Endocrine Society, San Francisco, CA, June 19-22, 2002, Abst S8-1, p 26.

Donaldson M. What is the role of growth-hormone therapy in short children who were small for gestational age. Lancet 358:347-348,2001.

Finkelstein BS, Imperiale TF, Speroff T, Marrero U, Radcliffe DJ, Cuttler L. Effect of growth hormone therapy on height in children with idiopathic short stature. A meta-analysis. Arch Pediatr Adolesc Med 156:230-240,2002.

Forsen T, Eriksson J, Tuomilheto J, Reunanen A, Osmond C, Barker D. The fetal and childhood growth of persons who develop type 2 diabetes. Ann Intern Med 133:176-182,2000.

Hattersley AT, Tooke JE. The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease. Lancet 353:637-1792,1999.

Kranzler JH, Rosenbloom AR, Proctor B, Diamond FB, Watson M. Is short stature a handicap? A comparison of the psychosocial functioning of referred and non-referred children with normal short stature and children with normal stature. J Pediatr 136:96-102,2000.

Ranke MB, Lindberg A. Growth hormone treatment of short children born small for gestational age or with Silver-Russell syndrome: results from KIGS (Kabi International Growth Study), including the first report on final height. Acta Paediatr Scand 417:18-26,1996.

Voss LD. Growth hormone therapy for the short normal child: who needs it and who wants it? The case against growth hormone therapy. J Pediatr 136:103-110,2000.

Wit JM, Rekers-Mombarg LTM, Dutch Growth Hormone Advisory Group. Final height gain by GH therapy in children with idiopathic short stature is dose dependent. J Clin Endocrinol Metab 87:604-611,2002.

Zucchini S, Cacciari E, Balsamo A, Cicognani A, Tassinari D, et al. Final height of short subjects of low birth weight with and without growth hormone treatment. Arch Dis Child 84:340-343,2001.

GROWTH HORMONE TREATMENT IN SHORT CHILDREN BORN SGA - FDA APPROVED AND RECOMMENDED

Robert Rapaport, MD
Emma Elizabeth Sullivan Professor and Chief,
Division of Pediatric Endocrinology and Diabetes,
Mount Sinai School of Medicine,
New York, NY

References
Albertsson-Wikland K, Karlberg J. Postnatal growth of children born small for gestational age. Acta Pediatr Suppl. 1997;423:193-5.

Alkalay AL, Graham JM, Pomerance JJ. Evaluation of neonates born with intrauterine growth retardation: review and practice guidelines. J Perinatol. 1998;18:142-51.

Chernausek SD, Breen TJ, Frank GR. Linear growth in response to growth hormone treatment in children with short stature associated with intrauterine growth retardation: The National Cooperative Growth Study experience. J Pediatr. 1996;128:S22-S27.

Czernichow P. Growth hormone treatment of short children born small for gestational age. Acta Paediatr Suppl. 1997;423:213-5.

de Zegher F, Albertsson-Wikland K, Wollmann HA, Chatelain P, Chaussain JL, Löfström A, et al. Growth hormone treatment of short children born small for gestational age: growth responses with continuous and discontinuous regimens over 6 years. J Clin Endocrinol Metab. 2000;85:2816-21.

Lapillonne A, Peretti N, Ho PS, et al. Aetiology, morphology and body composition of infants born small for gestational age. Acta Paediatr Suppl. 1997;423:173-6.

Larroque B, Bertrais S, Czernichow P, Leger J. School difficulties in 20-year-olds who were born small for gestational age at term in a regional cohort study. Pediatrics. 2001;108:111-115.

Lundgren EM, Cnattingius S, Jonsson B, Tuvemo T. Intellectual and psychological performance in males born small for gestational age with and without CUG. Pediatr Res. 2001;50:91-96.

Ranke MB, Lindberg A. Growth hormone treatment in children with short stature born small for gestational age or with Silver-Russell syndrome: results from KIGS (Kabi International Growth Study), including the first report on final height. Acta Paediatr Suppl. 1996;417:18-26.

Sas TC, Gerver WJ, de Bruin R, Mulder GH, et al. Body proportions during 6 years of GH treatment in children with short stature born small for gestational age participating in a randomised, double-blind, dose-response trial. Clin Endocrinol. 2000;53:675-681.

Sas T, Mulder P, Hokken-Koelega A. Body composition, blood pressure, and lipid metabolism before and during long-term growth hormone (GH) treatment in children with short stature born small for gestational age either with or without GH deficiency. J Clin Endocrinol Metab. 2000;85:3786-3792.

Strauss R S. Adult functional outcome of those born small for gestational age: twenty-six-year follow-up of the 1970 British birth cohort. JAMA. 2000;283:625-632.

Woods KA et al. IUGR and postnatal growth failure associated with IGF-1 Gene Deletion. N Eng J Med. 1996;335:1363.
October 2002