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 Marshall Klaus Perinatal Research Awards Archive2008 Klaus Awardees' Research Projects
This is an in vitro study using MASCs from transgenic mice to determine what factors (neurotrophins) are responsible for the migration to injured areas of brain which has been demonstrated in the laboratory's in vivo studies. Among the mechanisms to be investigated are inflammatory response and chemoattractants such as Stromal derived factor (SDF-1), Erythropoietin, BDNF, GDNF, NT-3, NGF, bFGF (basic fibroblast growth factor), and EGF. Overall goal is to identify factors present in post injury brain and to use in vitro approach to investigate which are responsible for migration of MASC's.
This is an in vitro study using lungs from timed pregnant mice at gestational day E14. Lungs will be allowed to develop to E 16.5 equivalent to canalicular and early saccular stage of lung development corresponding to 23 weeks human development. The hypothesis is that Hoxb5 and Hoxa5 regulation and expression patterns will be altered by hyperoxia (.4 FiO2) thereby arresting airway and alveolar development. The study will address the role of hyperoxia and subsequent hyperoxic lung injury on Hoxb5 and Hoxa5 expression and regulation and whether the effects of hyperoxia are dependent on changes in these Hox proteins. Stefanie Peterson Rogers (Mentor: Steven Abrams, MD) "Vitamin D Status and Impact on Bone Mineralization in Hispanic and Caucasian Infants."This is a prospective observational cohort study to evaluate the relative frequency of Vitamin D deficiency in Hispanic compared to Caucasian newborn infants in Houston, Texas. The hypothesis is that cord blood 25-hydroxyvitamin D (25-HOD) concentrations will be significantly lower in Hispanic infants and will lead to significant vitamin D deficiency in > 50% of Hispanic neonates. Vitamin D status and bone mineralization at birth will be evaluated. The effect of Vitamin D supplementation on 25-HOD and bone mineralization at three months will be assessed. |
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Martha Victoria Douglas-Escobar
Francheyska Silfa Mazara, Tufts University School of Medicine