1. Does mild hypoxic-ischemic encephalopathy adversely affect the neurodevelopmental outcome?

    Megan W. Berube, Mihai Puia-Dumitrescu, Ryan M. McAdams - University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

    EBM Lesson: Handling missing data

  2. Does high-dose erythropoietin decrease the risk of death or severe neurodevelopmental impairment in preterm infants?

    Molly C. Easterlin and Rangasamy Ramanathan, MD

    EBM Lesson: Missing Data and Multiple Imputation

  3. Does a lower interventional glucose threshold affect neurodevelopment in at-risk neonates?

    Carolyn McGann, Sarah Coggins, Kevin Dysart, MD

    EBM Lesson: Protocol adherence & Analysis

  4. Does prenatal surgical repair of myelomeningocele lead to better school-age outcomes?

    Faith Kim, David A. Bateman, Donna M. Garey

    EBM Lesson: Worst Rank Score Analysis

  5. Prediction Of Severe Retinopathy Of Prematurity In 24 To 30 Weeks Gestation Infants Using Birth Characteristics

    R.E. Zackula & Talkad S. Raghuveer - University of Kansas School of Medicine-Wichita

    EBM Lesson: Evaluation of a Prediction Model

  6. Precision medicine in neonatal hemodynamics: Need for prioritization of mechanism of illness and defining population of interest

    Adrianne Rahde Bischoff, Regan E Giesinger, Edward F Bell and Patrick J McNamara

    University of Iowa

    EBM Lesson: Definition of population of interest

  7. Can cord blood sampling delay the first packed red blood cell transfusion?

    Rupin Kumar, Brynne Sullivan

    University of Virginia Health System

    EBM Lesson: Mixed-Effects Models for analysis of differences in repeated measures


  1. Is routine evaluation of gastric residuals for premature infants safe or effective?

    Matthew A. Rysavy, Patricia L. Watkins, Tarah T. Colaizy, Abhik Das

    University of Iowa

    EBM Lesson: Multivariable models in the analysis of clinical trials

  2. Impactof Different Cord Clamping Strategies on Short Term Neuromonitoring Among Preterm Infants: A Randomized, Controlled Trial

    Prashant Agarwal, Amit Sharma, Ahmad Farooqi, Girija Natarajan

    Children’s Hospital of Michigan/Wayne State University, Detroit, MI

    EBM Lesson: Linear Mixed Model   

  3. Is glucose variability associated with worse brain function and seizures in neonatal encephalopathy?

    Jayasree Nair and Vasanth Kumar - University of Buffalo 

    EBM Lesson: Generalized estimating equations

  4. Management of non-vigorous newborns born through meconium stained amniotic fluid.
    Sourabh Verma, Tara M. Randis - New York University School of Medicine, New York

    EBM Lesson: Assessing Validity of Cohort Studies

  5. Is prophylaxis with early low-dose hydrocortisone in very preterm infants effective in preventing Bronchopulmonary Dysplasia?
    Neha Kumbhat, Alexis S. Davis, MD, William E. Benitz.  Stanford University, Palo Alto, CA

    EBM Lesson: Statistical heterogeneity

  6. Morphine Compared to Placebo for Procedural Pain in Preterm Infants: Safety, Efficacy and Equipoise.
    Omri David Soffer, Laura Cornelissen, Christy Cummings, Charles Berde. Boston Children's Hospital, Boston, MA

    EBM Lesson: Ethical challenges in conducting randomized controlled trials of analgesics in newborns

  7. Does ventriculomegaly without hemorrhage impact neurologic and behavioral outcomes of premature neonates?
    Ashley M. Lucke, Joseph L. Hagan, Michael D. Weiss - Children’s National Medical Center, DC; Baylor College of Medicine, Houston; University of Florida, Gainesville.

    EBM Lesson: Logistic Regression Analysis

  8. ​Early Limited Formula for Breastfeeding Infants: Too Much or Just Enough? 
    Miren B. Dhudasia, Dustin D. Flannery, Sagori Mukhopadhyay – Children’s Hospital of Philadelphia

    EBM lesson: Superiority, equivalence, and non-inferiority randomized controlled trials

  9. Andrew J. Groberg, and Jay M. Dintaman. Can Laryngeal Mask Airway Be Used for Surfactant Administration In Neonates?
    Walter Reed National Military Medical Center, Bethesda, MD

    EBM lesson: Interpreting trials stopped early 

  10. Joshua Clive Anchan, Nicholas Ryan Carr, Haashif Aqeeb Ahmad. Neonatal hypoglycemia: Is there a neurodevelopmental impact in early childhood?
    Brooke Army Medical Center, Fort Sam Houston, Texas and Pediatrix Medical Group of San Antonio, San Antonio, Texas

    EBM lesson: Sensitivity Analysis

  11. Kelsey A Montgomery, DO, MHA and Rebecca S Rose,. Can Nasal Continuous Positive Airway Pressure be used as a primary respiratory support for infants with Meconium Aspiration Syndrome? Riley Hospital for Children, Indianapolis. 

    EBM lesson: Permuted Blocked Randomization.

  12. Can Mixed Lipid Emulsion Prevent Parenteral Nutrition Associated Cholestasis? 
    Kate Tauber and David Clark; Albany Medical Center, Albany, NY

    EBM lesson: Chi Square Test

  13. Delayed Cord Clamping in Preterm Infants: Is it Time to Become Standard Practice?
    Elizabeth Sager, MD, Joseph Hagan, Shweta Parmekar - Texas Children's Hospital

    EBM lesson: Adjustment for Multiple Comparisons

  14. Should We Target Higher or Lower Oxygen Saturation Targets in the Preterm Infant?
    Sarah Drennan and Edgardo Szyld - University of Oklahoma Health Sciences Center, Oklahoma, USA

    EBM Lesson: Individual Participant Data versus Aggregate Data in Meta-analyses

  15. Is Early Caffeine Therapy Safe and Effective for Ventilated Preterm Infants?
    Viral G Jain, Vivek Saroha, Ravi Mangal Patel, Alan Jobe - Cincinnati Children's Hospital Hospital & Emory University

    EBM Lesson: Baseline imbalance in patient characteristics between treatment arms.


​​* Complete list of Journal Club Articles can be accessed on the AAP collaboration site here and in the Journal of Perinatology​.



The American Academy of Pediatrics Section on Neonatal Perinatal Medicine (AAP-SONPM) Journal Club is a collaboration between the American Academy of Pediatrics Section of Neonatal Perinatal Medicine, and the International Society for Evidence-Based Neonatology (EBNEO). All the Journal Club articles are peer-reviewed and published in the Journal of Perinatology. 

Goals of the Journal Club are:
  1. to provide education to trainees through both the content of the articles and the process of authoring the articles
  2. to encourage trainees to critically evaluate the written literature
  3. to expose trainees to the process of authorship and review

Journal Club Articles: Complete list of Journal Club Articles can be accessed at the Journal of Perinatology​ website.

To submit an article

Please see Guide to Authors on the Journal of Perinatology website. Submissions to Journal Club require pre-approval. Please contact Dr. Viral G Jain or Dr. Matthew Rysavy for additional information.

Editorial Board:

Haresh Kirpalani, MD, MSc
Children's Hospital of Philadelphia, Philadelphia, PA, USA

Alan Jobe, MD, PhD
Cincinnati Children's Hospital, Cincinnati, OH, USA

Clyde Wright, MD
Children's Hospital Colorado, Aurora, CO, USA

Wally Carlo, MD, FAAP
University of Alabama at Birmingham, AL, USA

Dmitry Dukhovny, MD, MPH, FAAP
Oregon Health & Science University, Portland, OR, USA

Ravi Mangal Patel, MD, MSc, FAAP
Emory University School of Medicine, Atlanta, GA, USA

Mark Hudak, MD, FAAP
University of Florida, Jacksonville, FL, USA

Brenda Poindexter, MD, FAAP
Emory University School of Medicine, Atlanta, GA, USA

Atul Malhotra, MD, PhD, FRACP- Monash Children's Hospital, Melbourne, Australia


Viral G. Jain, MD | University of Alabama at Birmingham, AL, USA

Matthew A. Rysavy, MD, PhD | University of Texas Health Science Center at Houston, TX, USA




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American Academy of Pediatrics