This resource provides practical considerations and strategies for professionals and organizations seeking to strengthen systems integration in support of adolescent and young adult substance use prevention, treatment, and recovery. The National Center for Adolescent & Young Adult Health and Well-Being and the National Council for Mental Wellbeing developed this resource through the Comprehensive Systems Integration for Adolescent and Young Adult Health project.

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Adolescent and young adult (AYA) substance use continues to be a significant public health concern. In the 2024 National Survey on Drug Use and Health (NSDUH), 9.3 million young adults reported binge drinking in the past month, and an estimated 26.8% of young adults needed substance use treatment.1 Effectively addressing AYA substance use requires systems integration, or the deliberate alignment of services across sectors, through cross-sector partnerships, early intervention, and coordinated care across systems. This resource provides practical considerations and strategies for professionals and organizations seeking to strengthen systems integration in support of AYA substance use prevention, treatment, and recovery. 

Most adults with substance use disorders began using in adolescence or young adulthood. With 10% of U.S. high school students reporting illicit drug use and 12% reporting misuse of prescription opioids in 2023,2 there is a clear need for early intervention approaches that connect AYA to timely, coordinated supports. 

AYA have unique psychological, developmental, and social needs, which means that substance use intervention and treatment approaches must create flexibility and tailored support in order to be effective. When systems integration is paired with flexible care models, AYA are better able to receive care in accessible settings, get treatment for multiple needs, and reconnect with services as needed. 

AYA don’t navigate systems—they navigate relationships. Strong, enduring connections between systems are what keep AYA connected to care, supported, and on a path to recovery. 

Resources to Share

The following resources are intended to support professionals and organizations across systems in implementing AYA substance use prevention, screening, engagement, referral, and recovery-support strategies. Resources may be used to inform practice, strengthen partnerships, support youth-centered communication, and identify tools for specific settings. 

Screening and Brief Intervention

Youth-Centered Education and Prevention Messaging

Treatment, Recovery, and Systems Supports


The Comprehensive Systems Integration for Adolescent and Young Adult Health (HRSA-23-079) project is supported by the Health Resources and Services Administration (HRSA) of the U.S. Department of Health and Human Services (HHS) as part of an award totaling $1,514,450 with 0% financed with non-governmental sources. The contents are those of the author(s) and do not necessarily represent the official views of, nor an endorsement, by, HRSA, HHS, or the U.S. Government. For more information, please visit HRSA.gov. 

Last Updated

08/17/2026

Source

American Academy of Pediatrics