As with all vaccines, it is critical that patients get vaccinated properly and safely with COVID-19 vaccine in order to be protected.


A supply check list is available from the CDC. You may want to remind patients to bring their own epinephrine autoinjectors if they have them.

Ancillary supply kits
The United States Government provides an ancillary supply kit to accompany doses of COVID-19 vaccine. The kits include supplies to prepare and administer vaccines. Single dose vials (for Pfizer-BioNTech vaccine, ages 12+ only) will not come with supply kits. See below for a list of specific supplies your office may expect.

Administration Supplies

  • Needles
    • For the pediatric formulation
      • All needles are 25 g 1-inch and retractable – this is based on ACIP recommendations – Needle Gauge and Length Chart
      • The government expects sufficient supply of 1-needles
    • For the adolescent/adult formulations
      • 25g 1-inch needles
      • 25g 1.5-inch needles
  • 1 mL syringes
  • Sterile alcohol wipes
  • Record cards
  • Some personal protective equipment for health care personnel

Diluting Supplies (if applicable)

  • 1.5 inch needles (to save the smaller ones for administration)
  • 3 or 5 mL syringes
  • Sterile alcohol wipes
  • Diluent

Vaccine Preparation for Pfizer-BioNTech Vaccine

Click here to view and download this information in a table.

Always follow the manufacturer’s instructions for dilution (when necessary) and administration. For the Pfizer-BioNTech vaccine, there are different dilution instructions for the different products. See the table below.

Dosing information for previously unvaccinated individuals is provided below. For more information on dosing for children who have already started their vaccination series and children with moderately to severely immunocompromising conditions, please see the AAP Vaccine Dosing Quick Reference Guide.

Vaccine Preparation for Moderna Vaccines

Click here to view and download this information in a table.

These vaccines may say “BOOSTER DOSES ONLY” Please disregard this. They are now used for vaccination series and additional doses.

Vaccine Preparation for Novavax Vaccine

Preparation Best Practices

  • Prepare vaccines in a designated area away from any space where potentially contaminated items are placed.
  • Only prepare vaccines when you are ready to administer them.
  • Always check expiration dates and confirm that you have selected the correct vaccine.


COVID-19 vaccines are administered via intramuscular (IM) injection. Infants (6 months – 12 months) should receive IM injection in the anterolateral thigh muscle. Children 1 year and older can receive IM injection in either the anterolateral thigh muscle or the deltoid muscle.

When co-administering with other vaccines, it is recommended that a different injection site (at least 1 inch apart) be used. If co-administered with a more reactogenic vaccine, consider using a different limb. See the AAP Vaccine Administration web page for more information.

Documenting COVID-19 Vaccination

COVID-19 vaccination record cards are provided as part of vaccine ancillary kits, and vaccination providers must complete these cards with accurate vaccine information (i.e., vaccine manufacturer, lot number, date of first dose administration, and second [and third if applicable] dose due date), and give them to each patient who receives vaccine to ensure a basic vaccination record is provided. Redundant methods and systems, such as immunization registries, should also be used to document vaccine receipt and remind vaccine recipients about their need for second doses.

FAQs for COVID Vaccine Administration

Visit the COVID-19 Vaccine Practice Implementation FAQs page for more information on

Additional Resources

Last Updated



American Academy of Pediatrics