The adolescent substance use landscape is shifting rapidly. Today’s youth face heightened risks from counterfeit pills, polysubstance use and unintentional opioid exposure, even those without traditional risk factors. 

Pediatricians play a vital role in early identification, compassionate intervention, and long-term support. This resource offers clinically grounded guidance to build comfort and confidence in screening for opioid use and connecting patients with evidence-based treatment and resources.

The Landscape Has Changed: What Pediatricians Need to Know 

What’s different about youth opioid exposure today? 

  • Today’s drug supply is unpredictable and dangerous.
  • Adolescents are now more likely to encounter powdered substances and counterfeit pills that look like legitimate prescription medications but may contain fentanyl or other synthetic opioids.
  • Polysubstance use including combinations of opioids, benzodiazepines and stimulants is common and increases overdose risk.
  • These trends have contributed to a sharp rise in overdose deaths, particularly among American Indian/Alaska Native and Latinx youth

What does the data tell us? 

  • After two decades of stability, adolescent overdose deaths began increasing in 2019.
  • Synthetic opioids like illicit fentanyl now drive the majority of these deaths.
  • Youth may unknowingly consume opioids through counterfeit pills or contaminated substances. 

Tools for Practice 

You don’t have to do this alone. Use these tools to screen, counsel, and refer confidently: 

Acknowledgment 

This project was funded by the Foundation for Opioid Response Efforts (FORE). The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies or stance, either expressed or implied, of FORE. FORE is authorized to reproduce and distribute reprints for Foundation purposes notwithstanding any copyright notation herein. 

Last Updated

08/26/2025

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