ASPIRE (Adolescent Substance use Prevention Intervention REsearch study)

aspire.pngLead Researchers: Sion Harris, PhD (Boston Children’s Hospital)
Lydia Shrier, MD, FAAP (Boston Children’s Hospital)


What Questions will this Study Answer?

  • Will a screening and brief intervention reduce heavy episodic drinking among at-risk adolescents?
  • Will a screening and brief intervention reduce key safety risks associated with alcohol use:
    • Riding with an impaired driver or
    • Driving while impaired?

Summary of Study Design:

  • Multi-site, cluster-randomized effectiveness trial
  • Clinicians will be randomized to the intervention or usual care group


  • 10 national PROS practices; about 40 clinicians
  • Over 1,300 youth ages 14-17 years old

Study Duration:

  • March 2022 – March 2025


  • National Institute on Alcohol Abuse and Alcoholism

Click here to see a full listing of PROS publications.

Last Updated



American Academy of Pediatrics